Gastrointestinal complications are frequently followed by combination chemotherapy. Based on recent reports, colitis is very rare but serious complication associated with taxane based chemotherapy. Despite of aggressive management, clinical course of colitis associated with chemotherapy is potentially fatal. We report the first case in Korea who was developed extensive colitis after docetaxel-based chemotherapy. A man aged 58 years with recurrent oral cavity carcinoma received chemotherapy with docetaxel, cisplatin and 5-fluorouracil (5-FU). On the 7th day of first cycle of chemotherapy, he complained of abdominal pain and fever, followed by hypotension because of large amount of hematochezia. Abdominal CT and colonoloscopy revealed extensive pancolitis with bleeding. He underwent two times of transarterial embolization with microcoils and gelform. Nevertheless these managements, bleeding foci were remained. Then, colonoscopic hemostasis such as hemoclipping and epinephrine injection were performed and fully recovered after 6 weeks.