Health geography has gained importance due to healthy smart cities, regions, and the integration of geo-internet and blockchain technologies. This study explores the intersection of geography and health, focusing on specific health challenges faced by individuals and groups. Using observational and descriptive methods, the study takes a regional approach to illuminate the socio-economic factors that are critical to addressing global health challenges. Drawing on academic literature and practical research, a concise case study of health challenges in Uzbekistan is presented, offering valuable insights. The analysis of data from informative articles and UN publications highlights the interdisciplinary nature of health geography and its practical applicability for researchers and policymakers. The findings underscore the important role of geography and health sciences in addressing region-specific diseases while highlighting the importance of spatial analysis in understanding environmental hazards and health impacts, including disease outbreaks.