Gastrointestinal xanthomas are characterized by foamy cytoplasmic cells containing lipid in lamina propria, and occur almostin the gastric mucosa. Colonic xanthomas have been described in rare case. All reported colonic xanthomas were located inrectosigmoid. Rectosigmoid xanthomas have tended to exhibit small polypoid lesion, on the contrary flat in stomach. We reporta case of xanthoma on ascending colon presenting as a laterally spreading tumor resected by endoscopic mucosal resection method.