Leiomyoma is a benign neoplasm that are thought to originate from the vascular smooth muscle. Leiomyoma more commonly found in the uterus, gastrointestinal tract, and skin. The nasal cavity is an uncommon site for a leiomyoma. We experienced a case of leiomyoma originating in the left nasal vestibule in a 64-year-old female. It was successfully removed by endoscopic surgery, and we report this case with a review of the related literatures.