Background and Objectives：The cessation of airflow in nasal cavity after total laryngectomy could influence the function and morphology of the nasal mucosa. The effect on human nasal mucosa after total laryngectomy was investigated with endoscopic photographs and biopsies. Subjects and Method：Twenty-two laryngectomees were studied and compared with 15 normal controls. Inferior turbinate was checked with 0 degree endoscopic photographs, and the RGB (Red,Green,Blue) scale was analysed by a histogram of adobe photoshop 6.0. In thirteen patients, inferior turbinate mucosa was taken for microscopic examination. Results：The difference of RGB scale between laryngectomees and normal control was statistically significant with the exception of the Red. Furthermore, the anterior part of the inferior turbinate was found to consist of ciliated columnar epitheliums which contained goblet cells. Conclusion：This study implicates that the stimulation of nasal airflow affects the function and morphology of the human nasal mucosa. (Korean J Otolaryngol 2004;47:650-4) KEY WORDS：Laryngectomy·Nasal mucosa·Histology·Respiration.