Natural products have been used as drugs for millennia, and the therapeutic potential of natural products has been studied formore than a century. Since the mid-1880s, approximately 60% of drugs have originated from natural products. Recently, theimportance of using natural products has increased, as has interest in discovering efficient new drugs. Natural drugs are desirablefor the treatment of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease. This review discusses thediscovery and development of drugs derived from natural products for the treatment of inflammatory bowel diseases.