Multiple myeloma (MM) is a malignant hematological neoplasia of plasma cells. The clinical manifestations of MM are heterogeneous and include monoclonal immunoglobulin production, hypogammaglobulinemia, impaired hematopoiesis, osteolytic bone disease, hypercalcemia, and renal dysfunction. Recently, novel agents such as thalidomide, lenalidomide, and bortezomib were introduced for the treatment of MM; treatment with these agents can effectively control both relapsed and newly diagnosed diseases and thereby improve survival.