at acute phase. Methods：In 123 patients with stroke and their family caregivers, data on care burden (Zarit Burden Interview) and various socio-demographic and clinical characteristics were obtained at 2 weeks after stroke. After uni- or bi-variate analyses, multiple linear regression tests were performed to determine the independent risk factors for care burden. Results：In the uni- or bi-variate analyses, five potential risk factors were identified: higher age, previous stroke, lower cognitive function and severer depressive symptom of stroke patients, and no aid carer of caregivers. In the multiple regression analyses, only the severer depressive symptom of stroke patients was identified as a determinant of care burden. Conclusion：To mitigate care burden during the acute phase of stroke, appropriate measures of clinical intervention need to be taken to prevent the depressive symptom of stroke patients. (J of Kor Soc for Dep and Bip Disorders 2010;8:95-101)