Pituitary abscesses are rare, but potentially life-threatening. Drainage of the abscess through a transsphenoidal approach is the standard treatment for a pituitary abscess. Recently, we experienced a patient with a Klebsiella pneumoniae pituitary abscess who was cured using antibiotics, without surgery. A 52-year-old man had a chronic, persistent headache for 1 month. Magnetic resonance imaging showed a fluid collection in his pituitary fossa. Pituitary hormone tests showed mild hypopituitarism. He was put on antibiotics and discharged after 6 weeks without sequelae. An early diagnosis and adequate antibiotics treatment for this life-threatening infection can result in an excellent prognosis.