Purpose: This study aimed to identify the relationship among post-traumatic stress disorder (PTSD), resilience, and retention intention in nurses who had experienced a traumatic event during hospital work. Methods: A structured questionnaire, was administered online from September 10 to September 22, 2021 to 198 nurses who had experienced a traumatic event during work at a university hospital in G metropolitan city. Data were analyzed using three-step mediated regression analysis. Results: Of the total participants, 70.7% had a high risk of PTSD. PTSD (β=-.20, p=.002) and resilience (β=.47, p<.001) had a direct effect on retention intention, and the explanatory power was 27.0%. However, the mediating effect of resilience on the relationship between PTSD and retention intention was not supported, which indicates that the relationship between post-traumatic stress and resilience was not significant (β=-.09, p=.232). Conclusion: Although there was no mediating effect of resilience, PTSD and resilience are considered to be important in order to improve nurses’ retention intention. It is needed to develop strategies to prevent the occurrence of traumatic events and to formulate policies and conduct programs for stress symptom management, aimed at increasing nurses’ resilience