Many organizations have spent huge investments on information systems (IS) but are unable to achieve the maximum benefits expected. The problem of system underutilization of implemented IS is a major factor that causes the lackluster returns on organizational investments in IS. In light of the need for solutions to underutilization, researchers are beginning to explore IS infusion to enhance task performance. IS infusion is the extent to which an individual fully uses the system to enhance his or her task performance. So far, there has yet to be any significant finding or theory to explain the phenomenon. Therefore this study offers a conceptual framework on IS infusion based on the socio-technical system perspective. Particularly, this study investigates the influence of job fit, task competence, technology competence, self-determination with technology and self-determination with task on IS infusion. The analysis following the collection of empirical data found that job fit and self-determination with technology are positively related to IS infusion. This study serves as a basis for future research and suggests important implication to managers and system designers in promoting IS infusion.