The purpose of this study was to investigate implant-supported restoration as a technique for restoring missing teeth in patients with aplastic anemia. Recurrent bleeding from wound sites leads to persistent release of iron in the tissue. Excessive iron in tissue is related to clinical findings,including fibrosis,poor wound healing, and high level of angiogenesis, which are possible etiological factors of reduced osseointegration. A 44-year-old female patient with aplastic anemia was treated with multiple endosseous implants throughout the mandible and in the posterior region of the maxilla. After 14 implants were placed, radiological and clinical parameters were assessed during the follow-up period. Marginal bone did not change significantlydur-ing the follow-up period. The finetrabecular bone in intimate contact and enclosing the implant fixturewas sufficientfor successful osseointegration. None of the 14 implants were associated with compilations during the seven-year experimental period. This study suggests that dental implant proce-dures are a safe and reliable treatment option for restoration of missing dentition in patients with aplastic anemia.