Pharyngocutaneous fistula (PCF) is a communication created between the pharynx and skinof the neck associated with flap reconstruction or primary closure of a pharyngeal defect. Inpatients who underwent laryngectomy and pharyngectomy, salivary accumulation in the deepneck space through the pharyngeal dehiscence can cause life-threatening complications,among which is carotid artery blow-out. Broad-spectrum antibiotics, compressive dressing,and artificial nutrition are usually applied first. Many closing methods have been studied, bothsurgically (direct repair or using flaps) and non-surgically (negative pressure therapy, hyperbaricoxygen therapy, or botulinum toxin injection). The use of a vacuum-assisted closure systemplaced endoluminally or externally has been recently reported to treat any leaks in the uppergastrointestinal tract. Here, we report a successfully-treated PCF using the endoluminal vacu-um-assisted closure system.