Background and Objectives This study compared two types of skin graft reconstructionfor the defect of the radial forearm free flap. Subjects and Method Ten cases of split-thickness skin graft (STSG) harvested from thethigh were analyzed. Also, ten cases of full-thickness skin graft (FTSG) harvest from the inguinalarea applied with vacuum-assisted closure (VAC) system were analyzed. Results The defect size of the radial forearm was increased more in the STSG group than inthe FTSG group (p＜0.05). Skin grafts were recovered completely sooner in the FTSG groupthan in the STSG group although it was not statistically significant (p=0.082). Five complications(pruritus, hypertrophic scar) were found in the donor site in the STSG group (p＜0.05). FTSG gave better scores according to the Vancouver Scar Scale in terms of pigmentation, pliability,and height (p＜0.05). Conclusion FTSG harvested from the inguinal area with the application of VAC system hasmany advantages for the defect of the radial forearm free flap although it is usually used forsmaller size defects than for STSGs.