Many studies have investigated relationships between APOE genotype and bone mineraldensity (BMD). However, the results of these studies have been inconsistent. Fewstudies have been carried out in Asian populations. We studied the relationship of theAPOE gene polymorphism and BMD in two large population-based studies. The datasetsincluded the Dong-gu Study (3575 men and 5335 women) and the Namwon Study(2310 men, 3512 women). Lumbar spine and femoral neck BMD were measured by dual-energy X-ray absorptiometry. APOE genotypes were analyzed by polymerase chainreaction?restriction fragment length polymorphism. The APOE genotypes were classifiedinto APOE E2 (E2/E2 and E2/E3), APOE E3 (E3/E3), and APOE E4 (E3/E4 andE4/E4). The genotype distribution of the study population was in Hardy-Weinbergequilibrium. There were no significant differences among APOE genotype groups inlumbar and femoral neck BMD in either cohort. Our data do not support the hypothesisthat the APOE genotype is associated with BMD.