The purpose of this study was to determine the detectable level and esthetically acceptable level of lip-line canting and investigate the difference between the perceptive abilities of dental professionals and laypersons. Hand-drawn frontal facial images with lip-line canting of 0?5 degrees were prepared. A set of 10 randomly organized images was given to four groups (orthodontists, general dentists, dental students, and laypersons) consisting of 20 evaluators each. A paper survey comprising questions on perception using the visual analog scale for esthetics was administered to the evaluators. All the groups detected the lip-line canting level when it was >2 degrees and did not perceive images of lip-line canting with minor variations of 0?2 degrees as unaesthetic. However, there were no statistical differences among the groups. The results of this study on the perception and esthetically acceptable level of lip-line canting can be a practical index in the diagnosis and treatment of patients with facial asymmetry and lip-line canting.