Ischemic stroke has been the leading cause deaths and the critical disability. In addition, the clinical problem of ischemic stroke have the poor prognosis and high mortally rate. The study aim was to identity the incidence variation of ischemic stroke by days of the week and its relationship with residences in males. We analyzed 607 males patients with ischemic stroke diagnosed by magnetic resonance image of computerized tomography. the were admitted to the oriental hospital of Kyunghee, Daejon, Wonkang university. We analyzed the onset of ischemic stroke using a chisquare test. The results showed significant weekly variation of ischemic stroke onset and the differences of weekly variation according to residences. A deeper knowledge of the underlying weekly variation could be provide more effective insights for preventive approach.