Recently, the underwater radiated noises generated from large commercial ships have become a globally important issue. Countries with large ports and environmental protection organizations demand strict safety guidelines in relation to underwater radiated noise. In this paper, the coupled PFFE/PFBE method is used to investigate the vibration and underwater radiated noise of a commercial ship. PFFEM is employed to analyze the vibrational responses of the commercial ship, and PFBEM is applied to analyze the underwater radiation noise. The vibrational energy of the structure is treated as an acoustic intensity boundary condition of PFBEM to calculate the underwater radiation noise. Numerical simulations are presented for the commercial ship under various frequencies, and reliable results are obtained.