Hemifacial spasm is characterized by symptoms of intermittent, irregular and involuntary movements (“twitching”) affecting the facial muscles that are controlled by the facial nerves unilaterally ? affecting one side of the face only. The demographics of this neurologic problem indicates incidence far more common in females than males, and it is usually seen in the fifth decade of life, or later. Edentulous patients with involuntary movements of facial muscles (such as hemifacial spasm) could encounter difficulties in maintaining the stability of their dentures. Not only would the proper and effective occlusion of thedentures be adversely affected, the harmony and compatibility with surrounding tissues (critical factors to be considered in any effort to fabricate a stable set of dentures) could be significantly degraded. This case report will therefore present and advance the concept of fabrication of complete ? and completely stable and wellfitting - dentures incorporating the concept of Neutral Zone.