While hydrogen is widely used, it has a low minimum ignition energy, raising safety concerns when using it. This research studied which parameters are the key variables in the hydrogen release and diffusion. These parameters were divided into six process variables in the initial release and two environmental variables in the dispersion. One hundred and twenty cases were selected through design of experiment, and the end-point in each case were analyzed using PHAST. Afterwards, an end-point prediction model was developed using RSM and ANOVA, and the impact of each variable on the endpoint was analyzed. As a result, the influence of eight variables was graded. The nozzle diameter had the greatest influence on the end-point, while the pipe roughness coefficient had no effect on the end-point. It is expected that these results will be used as basic data to improve safety across all fields of hydrogen handling facilities.