Objectives: This study aimed to develop, facilitate, and provide guidelines for a service design process using new online teaching and learning techniques to promote project-based learning. Methods:　 A patient experience-based nursing service design (PEN-SD) course comprised of four two-week sessions was conducted with 72 fourth-grade nursing students. Results: Guidelines and guide questions were provided during the orientation, team building, and the discover, define, develop, and deliver(4D) stages to ensure project success. As a result of this study, ten project themes were identifieded. Thise experience enhanced the development of students’ collaborative, empathetic, and creative problem-solving capabilities. Conclusions: The suggested guidelines can help instructors lead the PEN-SD process effectively, which can be a powerful tool for online team project learning in health profession education.