This case report describes a successful orthodontic treatment of a 26-year-old male patient with skeletal Class III and complete unilateral cleft lip and palate (CLP) on left side showed malformed microdontia on upper left lateral incisor and upper midline deviation to left side. To solve skeletal discrepancy, mandibular setback surgery and upper teeth extraction was performed. In order to easily correct the upper midline shifting, the 1st premolar was extracted on right side, while the lateral incisor was extracted on left side. In addition, to induce periodontal tissue regeneration, the left lateral incisor was extracted using forced eruption. After orthodontic treatment, the patient achieved improved facial profile and periodontal tissue on CLP area with favorable occlusion.