Purpose: This study aimed to compare the workload, work-related symptoms, perceived rewards, and expected rewards of frontline and non-frontline nurses during the coronavirus (COVID-19) pandemic and investigates the organizational strategies required by nurses to cope with its prolongment. Methods: A cross-sectional study involving 99 nurses, including frontline (n=67) and non-frontline nurses (n=32) working in a tertiary hospital with a dedicated ward for COVID-19 was conducted. The data were collected from December 2021 to January 2022. Data were analyzed using descriptive statistics, the x 2 test, Fisher’s exact test, and independent t-tests, and Mann Whitney U test. Results: Non-frontline nurses had heavier workloads and more severe work-related symptoms including burnout, stress, and fatigue than frontline nurses. Nurses’ perceived rewards for infection management and control were not equally distributed between the two groups. Nurses expected financial rewards including non-financial and reputation-related rewards. Conclusion: To prepare for future pandemics, medical stakeholders should develop effective strategies that include workforce management, equity-based rewards systems, and regular education and training in infection management and control for healthcare professio...