As micro-electronic devices are getting miniaturized, technology that can manage the temperature of confined area is required. On these demands, microchannel heat exchanger is suggested as promising solution. However, due to laminar flow created inside the microchannel with high Reynolds number suppresses diffusion based natural convection, leads to low heat transfer performance of microchannel. This paper shows how acoustic streaming flow enhances the heat transfer performance inside the microchannel without using additional structure or nanoparticle inside the straight microchannel and fluid numerically. Various parameters, such as Reynolds number (Re), initial displacement (ξ) was adopted to evaluate the influence of acoustic streaming flow. The results showed that acoustic streaming flow can disturb the thermal boundary, by creating the micro-vortex inside the straight-microchannel and enhance the heat transfer performance.