Purpose: In this study an examination was done of the effects of a team-based learning program on enhancement of communication competence for undergraduate nursing students in South Korea. Methods: A quasi-experimental method with a non-equivalent control group pre- and post-test design was used. Participants were 68 undergraduate nursing students recruited from two universities. The experimental group (n=35) received a 5-week team-based learning program on enhancement of communication competence, while the control group (n=33) received traditional lectures. Data were collected using self-report structured questionnaires before and after the intervention, and were analyzed using x2 tests, Fisher’s exact tests, and t-tests. Results: Compared to the control group, the experimental group reported significant positive changes in communication efficacy (t=2.58, p=.012), communication ability (t=12.01, p<.001), and learning satisfaction (t=2.11, p=.039). Conclusion: The findings indicate that this program is an effective intervention strategy to enhance communication competence for nursing students.