Purpose: This study examined the differences in drug abuse knowledge and drug usage attitudes among middle school students based on their diverse sociodemographic characteristics. Methods: This descriptive survey included 214 middle school students from five co-educational schools in G city. Data were collected from May 17th to June 17th, 2024, through a Google Forms survey distributed via QR codes. The data were analyzed using SPSS 27.0 for frequency, descriptive statistics, t-tests, one-way ANOVA, Scheffe post-hoc tests, Spearman's rank correlation, and multiple regression. Results: The study found that drug usage attitude had significant positive correlations with peer relationship satisfaction (rho=.26, p＜.001), school life satisfaction (rho=.18, p=.010), parental relationship (rho=.20, p=.004), academic performance (rho=.40, p＜.001), and drug abuse knowledge (rho=.35, p＜.001). Multiple regression analysis revealed that the main factors significantly influencing drug usage attitude were drug abuse knowledge (?=.37, p＜.001) and parental relationship (?=.18, p=.008). Drug abuse knowledge emerged as the most influential factor, while parental relationship was also a significant predictor. The regression model explained 22.3% of the variance in attitudes towards drug use (F=...