In this study, we developed a simulation methodology for a technology that rapidly cools molds by directly spraying them with CO2 in its liquefied gaseous state. Initially, a simulation verification process was conducted using ANSYS Fluent’s heat transfer analysis based on temperature values measured in prior research experiments, ensuring a comparable temperature could be calculated. Subsequently, the validated analysis method was employed to evaluate design factors that exert the most significant influence on cooling. An evaluation was conducted based on three factors: part thickness, mold thickness, and the melting temperature of material. Using a full factorial design approach, a total of 27 analyses were completed and subsequently calculated through analysis of means. The impact assessment was carried out based on the temperature values at the product's core. The results indicated that the thickness of the mold had the highest influence, while the melting temperature of material had the least.