This study investigated the effects of job stress, job attitude, and social support on the relationship between client violence and social worker job response. The multi-mediating effect of job stress, job attitude, and social support between client violence and social worker job response was empirically analyzed. 257 social workers in social welfare facilities were analyzed using SPSS. The following conclusions were drawn. First, there was a significant correlation between client violence, job stress, job attitude, social support, and job response variables. Client violence was affecting variables related to social worker job response. Second, job stress, job attitude, and social support had multiple mediating effects. The parallel mediation effect and the serial mediation effect were verified. Third, job attitude was found to be a variable of multiple mediating effects. Fourth, job stress and social support were found to be double mediating effect variables. In response, programs and manuals suitable for the type of social welfare facilities and the policy basis for preparing countermeasures for social workers were limited, and follow-up studies on various variables were suggested.