Objectives: The purpose of this study is to identify the factors affecting the stress perception of residents in Gyeongsangnam-do in COVID-19 using the original data of the Community Health Survey by the Korea Centers for Disease Control and Prevention, and to suggest effective stress perception man- agement strategies based on this. Methods: Data of 229,270 original data from the Community Health Survey of the Korea Centers for Disease Control and Prevention in 2020 during the COVID-19 epidemic period were collected. Frequency analysis and cross-analysis were conducted using SPSS Statistics 27 to identify the factors affecting the stress perception of residents in Gyeongsangnam-do in COVID-19, and a step-by-step selection method of logistic regression analysis was conducted to establish a stress perception management strategy. Results: As a result of this study, women in gender 1.80 (95% confidence interval, CI = 1.21-2.67), age 19-44 years 7.68 (95% CI = 2.36-25.00) and 45-64 years old (95% CI = 1.46-4.21) and occupational administrative 4.50 (95% CI = 1.89-10.70), Less than 1 million won in monthly household income is 4.66 (95% CI = 1.95-11.15) and 100-3 million won is 2.31 (95% CI = 1.00-5.31), residence, Jinhae-si 1.42 (95% CI = 0.44-4.62), Sacheon-si 1.73 (95% CI = 0.61-4.89), Gimhae-si 2.04 (95% CI = 0.68-6.11), Masan-si 1.36 (95% CI = 0.41-4.54), Jinju-si 2.26 (95% CI = 0.77-6.65), Changwon-si 1.19 (95% CI = 0.40-3.52), Currently, smoking oil was 2.02 (95% CI = 1.17-3.47) in the pres- ence or absence of smoking. Conclusions: Based on these results, in order to manage short-term stress awareness in Gyeongsangnam-do during the COVID-19 era, it is necessary to strategically implement stress management projects for women with monthly household income of less than 1 million won and 100-3 million won among residents in Jinhae, Sacheon, Gimhae, and Changwon.