The aim of this study was to investigate that listening to music reduces the anxiety and distress of the patients who underwent ultrasound guided core biopsy in a clinic. One hundred patients underwent Ultrasound Guided Core Biopsy of the Breast. Each patients was allocated to one of two groups with different methods whether they listened to music or not. The experimental group listening to music are 50 patients and the control group are 50 patients. The difference of VAS anxiety score of pre-test and post-test was significant (p<0.001). Compared by the control group, the subjective distress of the patients listening to music such as pain and tension was significant (p<0.001) but nausea and dyspnea was not significant. The objective distress of the patients listening to music was statistically significant (p<0.001). The Differances of systolic blood pressure, diastolic blood pressure, pulse between pre-test and post-test were not significant. The results suggest that listening to music reduces the anxiety and distress of the patients who underwent ultrasound guided core biopsy in a clinic.