Purpose: This study aimed to determine the effects of puerperium maternal anxiety, quality of marital relationship, and postpartum blues on late postpartum depression. Methods: Participants were 130 postpartum women who delivered healthy babies, and answered self-administered questionnaires, such as Edinburgh Postpartum Depression Scale (EPDS-K), Spielberger’s State Anxiety Inventory, and Quality of Marital Relationships during the 1st week of delivery and 4？6 weeks postpartum. Data were analyzed using t-test, ANOVA, Spearman''s rho correlation coefficient, and hierarchical stepwise multiple regression analysis. Results: The point prevalence of postpartum depression (EPDS-K ≥10, cut-off score) was 23.1% at early postpartum and 16.9% at late postpartum. Predictors of late postpartum depression were early postpartum depression (β= 0.86), the difference between early and late postpartum anxiety (β=0.19), and the difference between early and late Quality of Marital Relationships (β=-0.13) (F=70.52, p<0.001). The total vatiance explained was 76.5%. Conclusion: It is recommended that a maternal management system should be established at maternity hospitals to screen new mothers’ depression and anxiety risks during the early postpartum stage