Purpose: The purpose of this study was to examine the effects of a parental education program based on the Satirtransformational systemic therapy model on self-esteem, congruence, parent-child communication, and parentingsense of competence of the preschoolers’ mothers. Methods: Non-equivalent control group pretest and posttestdesign was used. The participants were 36 (experimental group 18, control group 18) preschoolers’ motherswho volunteered from kindergartens and children''s homes. The treatment for this study was based on Satir''s systemictraining program for parenting skills. Data were analyzed using percentage, x2-test, t-test and t-test withSPSS 21.0 Version. Results: Statistically, there were significant increase in self-esteem, congruence, parent-childcommunication, and parenting sense of competence in the experimental group compared to the control group. Conclusion: Findings suggested that parental education program based on the Satir transformational systemictherapy model can be used by preschoolers’ mothers for effective psychiatric nursing interventions in parentingand preschoolers’ mental health promotion.