Purpose: The purpose of this study was to examine the effects of music therapy on pain, depression, and anxiety in terminally ill patients. Methods : Twenty patients in the experimental group were provided with music via headphones for 30- 40 min at a time as they requested for 2 weeks, whereas no music was provided for the nineteen patients in the control group. Data were collected using a questionnaire. The research instruments included Visual Analog Scale (VAS) and Depression & Anxiety Inventory Scale. Data were analyzed using c2-test, t-test, and Fisher’s exact test, using SPSS 15.0. Results : There were significant decreases in the scores of pain at present (t=-2.54, p<.05), depression (t=-2.187, p<.05) and anxiety (Z=-2.114, p<.05) in the experimental group compared to those in the control group. Conclusion : Music therapy is considered non-invasive and inexpensive intervention and can be easily applied to alleviate pain, depression and anxiety for terminally ill patients.