The purpose of this study was to test the moderating effect of ego-resilience in relation between perfectionism and the stress of athletes in university. The participants were 323 athletes in university. All the students administered three instruments, Perfectionism scale, Ego-resilience scale, Stress scale. The results of this study were as follows: First, there are significient relationship among perfectionism, ego-resilience, stress. Second, it was proved that ego-resilience exerted as moderating variable between perfectionism and stress of athletes in university. The implications of this study were investigated variables regarding stress to help athletes in university. Based on the finding results, how to increase ego-resilience and reduce perfectionism were suggested.