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논문 리스트

2006
결정성근막염양 버팀질을 가진 갑상샘 유두암종: 1예 보고 Thyroid Papillary Carcinoma with Exuberant Nodular Fasciitis-like Stroma: A Case Report
대한병리학회
논문정보
Publisher
대한병리학회지
Issue Date
2006-02-01
Keywords
-
Citation
-
Source
-
Journal Title
-
Volume
40
Number
1
Start Page
76
End Page
79
DOI
ISSN
03791149
Abstract
Thyroid papillary carcinoma (TPC) with exuberant nodular fasciitis-like stroma is one of the rare variants of TPC. To date, only 19 cases have been reported in the English medical literature. We report here on the the first Korean case of TPC that contained a prominent nodular fasciitis-like stroma. A 40-year-old female presented with a hard painless right neck mass that had been present for two months. Total thyroidectomy disclosed a solitary nodule in the mid portion of the right lobe that measured 25×20 mm. The tumor was well delineated, but it was not encapsulated. Microscopically, the tumor was a typical papillary carcinoma except that large areas of the tumor were occupied by a stroma composed of irregular fascicular spindle cells. The stromal component accounted for 60% of the tumor mass. The spindle cells exhibited neither atypism nor mitosis, and the tumor’s extensive stromal cell proliferation resembled the appearance of nodular fasciitis of the soft tissues. Immunohistochemically, the spindle cells were positive for vimentin and -smooth muscle actin, but they were negative for thyroglobulin, thyroid transcription factor-1, S-100 protein, CD34 and desmin, and this represents myofibroblastic features.

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