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2006
결정성근막염양 버팀질을 가진 갑상샘 유두암종: 1예 보고
Thyroid Papillary Carcinoma with Exuberant Nodular Fasciitis-like Stroma: A Case Report
대한병리학회
논문정보
- Publisher
- 대한병리학회지
- Issue Date
- 2006-02-01
- Keywords
- -
- Citation
- -
- Source
- -
- Journal Title
- -
- Volume
- 40
- Number
- 1
- Start Page
- 76
- End Page
- 79
- DOI
- ISSN
- 03791149
Abstract
Thyroid papillary carcinoma (TPC) with exuberant nodular fasciitis-like stroma is one of the
rare variants of TPC. To date, only 19 cases have been reported in the English medical literature.
We report here on the the first Korean case of TPC that contained a prominent nodular
fasciitis-like stroma. A 40-year-old female presented with a hard painless right neck mass that
had been present for two months. Total thyroidectomy disclosed a solitary nodule in the mid
portion of the right lobe that measured 25×20 mm. The tumor was well delineated, but it was
not encapsulated. Microscopically, the tumor was a typical papillary carcinoma except that
large areas of the tumor were occupied by a stroma composed of irregular fascicular spindle
cells. The stromal component accounted for 60% of the tumor mass. The spindle cells exhibited
neither atypism nor mitosis, and the tumor’s extensive stromal cell proliferation resembled
the appearance of nodular fasciitis of the soft tissues. Immunohistochemically, the spindle
cells were positive for vimentin and -smooth muscle actin, but they were negative for
thyroglobulin, thyroid transcription factor-1, S-100 protein, CD34 and desmin, and this represents
myofibroblastic features.
- 전남대학교
- KCI
- 대한병리학회지
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