This study examines the mediating effects of social support on 1) the relationships between acculturative stress and depression/anxiety and 2) the relationships between emotional control and depression/anxiety in children from multicultural families. Pearson‘s correlations between variables were analyzed, and hierarchical regression analyses were conducted to identify direct and indirect effects of acculturative stress, emotional control, and social support on children’s depression/anxiety. The sample included a total of 199 primary school students in grades 3 to 6 who lived in the Gwangju or Chonnam regions of Korea. First, there were positive correlations between acculturative stress and depression/anxiety and negative correlations between emotional control and social support. Second, social support from both peers and teachers partially mediated the relationships between acculturative stress and depression/anxiety. Third, social support from peers fully mediated the relationships between emotional control and depression/anxiety, and that from teachers partially mediated these relationships. The results suggest that social support from peers and teachers may reduce depression/anxiety in multicultural children as a mediating variable.