Objectives: To investigate the factors influencing the experience of oral symptoms in Korean adolescents. Methods: In total, 52,795 adolescents were selected from the web-based 2023 Korean Youth Risk Behavior survey conducted by the Korean Disease Control and Prevention Agency. Data were analyzed in SPSS 21.0 using the combined sample analysis method. Results: After adjusting for all variables, sex, grade, academic achievement, economic status, alcohol consumption, consumption of carbonated beverage and fast food, frequency of brushing, brushing after lunch, sleep, sadness and despair, loneliness, and anxiety disorder were statistically significantly associated with tooth fracture, toothache, gingival pain and bleeding. Conclusions: It is necessary to recognize, at an early stage, the risks factors that might affect dietary intake behavior, oral health behavior, mental health, and oral diseases in Korean adolescents. Based on this, appropriate oral health education should be provided to adolescents and changes should be encouraged to assist in establishing positive oral and mental health behaviors.